Welcome to Xu Lab

Discovering Hidden Biology to Develop Next-Generation Cancer Therapies

Cancer evolves by continuously adapting to therapeutic pressure, yet many of the molecular mechanisms driving tumor progression, lineage plasticity, and drug resistance remain hidden. The Xu Laboratory is dedicated to uncovering these previously unrecognized biological mechanisms and translating fundamental discoveries into innovative therapeutic strategies for aggressive cancers.

Our research integrates cancer epigenetics, targeted protein degradation (PROTACs), tumor lineage plasticity, precision oncology, and cancer immunology to understand how tumors evolve and how these mechanisms can be therapeutically exploited. We combine molecular biology, functional genomics, CRISPR screening, multi-omics, computational biology, and drug discovery to identify new vulnerabilities in breast cancer, prostate cancer, and glioblastoma.

Our ultimate mission is to transform fundamental biological discoveries into precision therapies that improve the lives of cancer patients.